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Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?
Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …
Rethinking ovarian cancer: recommendations for improving outcomes
There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
Some stimulatory receptors of the innate immune system, such as the NKG2D receptor (also
called KLRK1) expressed by natural killer cells and activated CD8+ T cells, recognize self …
called KLRK1) expressed by natural killer cells and activated CD8+ T cells, recognize self …
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
A Carnero, C Blanco-Aparicio, O Renner… - Current cancer drug …, 2008 - ingentaconnect.com
PTEN/PI3K/AKT constitutes an important pathway regulating the signaling of multiple
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …
The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models
When PI3K (phosphatidylinositol-3 kinase) is activated by receptor tyrosine kinases, it
phosphorylates PIP2 to generate PIP3 and activates the signaling pathway. Phosphatase …
phosphorylates PIP2 to generate PIP3 and activates the signaling pathway. Phosphatase …
Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus
Personalized cancer medicine is based on the concept that targeted therapies are effective
on subsets of patients whose tumors carry specific molecular alterations. Several …
on subsets of patients whose tumors carry specific molecular alterations. Several …
PTEN, more than the AKT pathway
C Blanco-Aparicio, O Renner, JFM Leal… - …, 2007 - academic.oup.com
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/phosphatidylinositol 3-
kinase (PI3K)/AKT constitute an important pathway regulating the signaling of multiple …
kinase (PI3K)/AKT constitute an important pathway regulating the signaling of multiple …
[ספר][B] Textbook of personalized medicine
KK Jain - 2015 - Springer
Molecular diagnostics, the use of diagnostic testing to understand the molecular
mechanisms of an individual patient's disease, will be pivotal in the delivery of safe and …
mechanisms of an individual patient's disease, will be pivotal in the delivery of safe and …
Epithelial ovarian cancer experimental models
Epithelial ovarian cancer (OvCa) is associated with high mortality and, as the majority (>
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival …
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival …
The PKB/AKT pathway in cancer
A Carnero - Current pharmaceutical design, 2010 - ingentaconnect.com
PKB/AKT constitutes an important pathway that regulates the signaling of multiple essential
biological processes. PTEN is a dual protein/lipid phosphatase whose main substrate is …
biological processes. PTEN is a dual protein/lipid phosphatase whose main substrate is …