Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

Peptides are a rapid-growing class of therapeutics with unique and desirable
physicochemical properties. Due to disadvantages such as low membrane permeability and …

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one
of the most important prognostic factors, with children less than 1 year old having favorable …

Obesity is a multifactorial and complex disease that often manifests in early childhood with a
lifelong burden. Polygenic and monogenic obesity are driven by the interaction between …

Background Increasing prevalence of morbid obesity accompanied by comorbidities like
type 2 diabetes mellitus (T2DM) led to a demand for improving therapeutic strategies and …

Obesity is a major global concern and is generally attributed to a combination of genetic and
environmental factors. Several hypotheses have been proposed to explain the evolutionary …

Multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the central
nervous system (CNS), is a major clinical and societal problem, which has a tremendous …

The melanocortin system is a complex set of molecular mediators and receptors involved in
many physiological and homeostatic processes. These include the regulation of …

The melanocortin system encompasses melanocortin peptides, five receptors, and two
endogenous antagonists. Besides pigmentary effects generated by α-Melanocytic Hormone …

Obesity has emerged as a critical and urgent health burden during the current global
pandemic. Among multiple genetic causes, melanocortin receptor‐4 (MC4R), involved in …