Nano-based approved pharmaceuticals for cancer treatment: present and future challenges

F Rodríguez, P Caruana, N De la Fuente, P Español… - Biomolecules, 2022 - mdpi.com
Cancer is one of the main causes of death worldwide. To date, and despite the advances in
conventional treatment options, therapy in cancer is still far from optimal due to the non …

Nanosafety research—are we on the right track?

HF Krug - Angewandte Chemie International Edition, 2014 - Wiley Online Library
The number of studies that have been published on the topic of nanosafety speaks for itself.
We have seen an almost exponential rise over the past 15 years or so in the number of …

Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model

M Moglianetti, E De Luca, D Pedone, R Marotta… - Nanoscale, 2016 - pubs.rsc.org
In recent years, the use of nanomaterials as biomimetic enzymes has attracted great interest.
In this work, we show the potential of biocompatible platinum nanoparticles (Pt NPs) as …

[HTML][HTML] In vitro and in vivo evaluation of degradation, toxicity, biodistribution, and clearance of silica nanoparticles as a function of size, porosity, density, and …

SPH Moghaddam, R Mohammadpour… - Journal of controlled …, 2019 - ncbi.nlm.nih.gov
Abstract Silica nanoparticles (SiO 2 NPs) have potential utility in controlled release. Despite
significant research in this area, there is a gap in the understanding of the correlation …

In vitro methods for assessing nanoparticle toxicity

DT Savage, JZ Hilt, TD Dziubla - Nanotoxicity: Methods and protocols, 2019 - Springer
As a consequence of their increase in annual production and widespread distribution in the
environment, nanoparticles potentially pose a significant public health risk. The sought-after …

Endotoxin contamination: a key element in the interpretation of nanosafety studies

Y Li, D Boraschi - Nanomedicine, 2016 - Taylor & Francis
The study of toxicity and potential risks of engineered nanoparticles is of particular
importance in nanomedicine. Endotoxin, a common contaminant of bacterial origin, has …

Pre-clinical immunotoxicity studies of nanotechnology-formulated drugs: Challenges, considerations and strategy

MA Dobrovolskaia - Journal of Controlled Release, 2015 - Elsevier
Assorted challenges in physicochemical characterization, sterilization, depyrogenation, and
in the assessment of pharmacology, safety, and efficacy profiles accompany pre-clinical …

Facilitating the translation of nanomedicines to a clinical product: challenges and opportunities

V Agrahari, V Agrahari - Drug Discovery Today, 2018 - Elsevier
Highlights•Clinical translation and commercialization challenges of nanomedicine products.•
Manufacturing or scale-up, characterization, safety, stability and efficacy …

[HTML][HTML] Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and …

B Halamoda-Kenzaoui, RJ Vandebriel… - Journal of Controlled …, 2021 - Elsevier
Nanotechnology-based health products are providing innovative solutions in health
technologies and the pharmaceutical field, responding to unmet clinical needs. However …

Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy

L Farcal, F Torres Andón, L Di Cristo, BM Rotoli… - PloS one, 2015 - journals.plos.org
Nanomaterials (NMs) display many unique and useful physico-chemical properties.
However, reliable approaches are needed for risk assessment of NMs. The present study …