The successful landmark discovery of mouse and human inducible pluripotential stem cells
(iPSC's) by Takahashi and Yamanaka in 2006 and 2007 has triggered a revolution in the …

The transplanting islets to the liver approach suffers from an immediate posttransplant loss
of islets of more than 50%, progressive graft dysfunction over time, and precludes recovery …

Over the past few years, extensive efforts have been made to generate in-vitro pancreatic
micro-tissue, for disease modeling or cell replacement approaches in pancreatic related …

Type 1 diabetes is caused by insulin deficiency due to the loss of beta cells in the islets of
Langerhans. In severe cases, islet transplantation into the portal vein is performed …

Since the identification of four different pancreatic β-cell subtypes and bi-hormomal cells
playing a role in the diabetes pathogenesis, the search for in vitro models that mimics such …

Loss and functional failure of pancreatic β-cells results in disruption of glucose homeostasis
and progression of diabetes. Although whole pancreas or pancreatic islet transplantation …

Differentiation of human pluripotent stem cells towards definitive endoderm (DE) is the
critical first step for generating cells comprising organs such as the gut, liver, pancreas and …

Background This study was designed to generate functional insulin-producing cells (IPCs)
from dental-derived mesenchymal stem cells (MSCs) and further explore their therapeutic …

The reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) has raised
extreme hope among both scientists and society by means of development of personalized …

Cell encapsulation and cell delivery have been proposed as an alternative approach to treat
various diseases since they allow localized and controlled delivery of therapeutic cells to …