Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic
organisms. They form the cell cytoskeleton, and its function is essential for a large number of …

Microtubules are highly dynamic structures, which consist of α-and β-tubulin heterodimers,
and are involved in cell movement, intracellular trafficking, and mitosis. In the context of …

Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …

Nearly 100 proteins are known to be regulated by hsp90. Most of these substrates or “client
proteins” are involved in signal transduction, and they are brought into complex with hsp90 …

Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

Prostate cancer progression requires active androgen receptor (AR) signaling which occurs
following translocation of AR from the cytoplasm to the nucleus. Chemotherapy with taxanes …

Although the mechanisms of toxic activity of tau are not fully recognized, it is supposed that
the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It …

Loss of the p53 tumor suppressor pathway contributes to the development of most human
cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant …

The transcription factor, p53, is critical for many important cellular functions involved in
genome integrity, including cell cycle control, DNA damage response, and apoptosis …

One protein—p53—plays nemesis to most cancers by condemning damaged cells to death
or quarantining them for repair. But the activity of p53 relies on its intact native conformation …