The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

The blood-brain barrier (BBB) is a physical and biochemical barrier that precisely controls
cerebral homeostasis. It also plays a central role in the regulation of blood-to-brain flux of …

Abstract Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a
global epidemic, and so far, there is neither cure nor treatment to alter its progression. The …

Traumatic brain injury causes inflammation and glial scarring that impede brain tissue
repair, so stimulating angiogenesis and recovery of brain function remain challenging. Here …

Historically, the brain has been considered an immune-privileged organ separated from the
peripheral immune system by the blood–brain barrier. However, immune responses do …

Ischemic stroke is a highly complex and devastating neurological disease. The sudden loss
of blood flow to a brain region due to an ischemic insult leads to severe damage to that area …

Ischemic stroke is a major cause of disability and mortality worldwide, but effective
restorative treatments are very limited at present. Regenerative medicine research revealed …

3300 Stroke November 2019 allow more realistic and precise testing of cell delivery
techniques including stereotaxic and intra-arterial cell administration and dose translation to …

Cell-based therapies hold great promise for brain repair after stroke. While accumulating
evidence confirms the preclinical and clinical benefits of cell therapies, the underlying …

Stroke is a prevalent global acute cerebrovascular condition, with ischaemic stroke being
the most frequently occurring type. After a stroke, neutrophils accumulate in the brain and …