Fluorescent nanoparticles for super-resolution imaging

W Li, GS Kaminski Schierle, B Lei, Y Liu… - Chemical …, 2022 - ACS Publications
Super-resolution imaging techniques that overcome the diffraction limit of light have gained
wide popularity for visualizing cellular structures with nanometric resolution. Following the …

Understanding cell penetration of cyclic peptides

PG Dougherty, A Sahni, D Pei - Chemical Reviews, 2019 - ACS Publications
Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

Cell penetrating peptides: classification, mechanisms, methods of study, and applications

A Gori, G Lodigiani, SG Colombarolli… - …, 2023 - Wiley Online Library
Cell‐penetrating peptides (CPPs) encompass a class of peptides that possess the
remarkable ability to cross cell membranes and deliver various types of cargoes, including …

Application of semiconductor quantum dots in bioimaging and biosensing

IV Martynenko, AP Litvin, F Purcell-Milton… - Journal of Materials …, 2017 - pubs.rsc.org
In this review we present new concepts and recent progress in the application of
semiconductor quantum dots (QD) as labels in two important areas of biology, bioimaging …

New modalities for challenging targets in drug discovery

E Valeur, SM Guéret, H Adihou… - Angewandte Chemie …, 2017 - Wiley Online Library
Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

[HTML][HTML] Membrane active peptides and their biophysical characterization

FG Avci, B Sariyar Akbulut, E Ozkirimli - Biomolecules, 2018 - mdpi.com
In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …

[HTML][HTML] Stapled peptides—a useful improvement for peptide-based drugs

M Moiola, MG Memeo, P Quadrelli - Molecules, 2019 - mdpi.com
Peptide-based drugs, despite being relegated as niche pharmaceuticals for years, are now
capturing more and more attention from the scientific community. The main problem for …

Emerging methods and design principles for cell‐penetrant peptides

L Peraro, JA Kritzer - Angewandte Chemie International Edition, 2018 - Wiley Online Library
Biomolecules such as antibodies, proteins, and peptides are important tools for chemical
biology and leads for drug development. They have been used to inhibit a variety of …

Evaluation of the cytosolic uptake of HaloTag using a pH-sensitive dye

JLB Giancola, JB Grimm, JV Jun, YD Petri… - ACS chemical …, 2024 - ACS Publications
The efficient cytosolic delivery of proteins is critical for advancing novel therapeutic
strategies. Current delivery methods are severely limited by endosomal entrapment, and …

Recent progress of food‐derived bioactive peptides: Extraction, purification, function, and encapsulation

Y Jiang, J Sun, J Chandrapala, M Majzoobi… - Food …, 2024 - Wiley Online Library
Functional peptides constitute a class of small molecular peptide chains with specific
functions in biology and are typically composed of various amino acids. The chemical …