PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
ROS and ROS‐mediated cellular signaling
J Zhang, X Wang, V Vikash, Q Ye, D Wu… - Oxidative medicine …, 2016 - Wiley Online Library
It has long been recognized that an increase of reactive oxygen species (ROS) can modify
the cell‐signaling proteins and have functional consequences, which successively mediate …
the cell‐signaling proteins and have functional consequences, which successively mediate …
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism
as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative …
as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative …
Signaling and function of interleukin-2 in T lymphocytes
The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the
immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling …
immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling …
[HTML][HTML] Insulin/insulin-like growth factor signaling in C. elegans
The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …
growth, development, longevity, and behavior. This fundamental pathway is regulated by …
Oxidative stress and antioxidants in disease and cancer: a review
Reactive oxygen species (ROS), highly reactive molecules, are produced by living
organisms as a result ofnormal cellular metabolism and environmental factors, and can …
organisms as a result ofnormal cellular metabolism and environmental factors, and can …
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
MA Lawlor, DR Alessi - Journal of cell science, 2001 - journals.biologists.com
The serine/threonine protein kinase PKB (also known as Akt) is thought to be a key mediator
of signal transduction processes. The identification of PKB substrates and the role PKB …
of signal transduction processes. The identification of PKB substrates and the role PKB …
CD28-mediated co-stimulation: a quantitative support for TCR signalling
O Acuto, F Michel - Nature Reviews Immunology, 2003 - nature.com
The ability of naive T cells to clonally expand and acquire effector functions depends on the
strength of signals received by the T-cell receptor (TCR) and by an array of co-stimulatory …
strength of signals received by the T-cell receptor (TCR) and by an array of co-stimulatory …
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
Introduction The persistence of circulating tumor cells (CTC) in breast cancer patients might
be associated with stem cell like tumor cells which have been suggested to be the active …
be associated with stem cell like tumor cells which have been suggested to be the active …
PI3k/AKT signaling pathway: Erythropoiesis and beyond
Erythropoiesis is a multi‐step process that involves the differentiation of hematopoietic stem
cells into mature red blood cells (RBCs). This process is regulated by several signaling …
cells into mature red blood cells (RBCs). This process is regulated by several signaling …