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The link between circulating follicular helper T cells and autoimmunity
Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …
centres that allow affinity maturation of antibody responses. Although usually located in …
T follicular helper cell biology: a decade of discovery and diseases
Hel** B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis
Follicular helper T (TFH) cells are a specialized subset of CD4+ T cells that essentially
support germinal center responses where high-affinity and long-lived humoral immunity is …
support germinal center responses where high-affinity and long-lived humoral immunity is …
[HTML][HTML] Functional SARS-CoV-2-specific immune memory persists after mild COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a
global pandemic, and cases continue to rise. Most infected individuals experience mildly …
global pandemic, and cases continue to rise. Most infected individuals experience mildly …
[HTML][HTML] Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
effective in preventing hospitalization from severe COVID-19. However, multiple reports of …
effective in preventing hospitalization from severe COVID-19. However, multiple reports of …
Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
dramatically expedited global vaccine development efforts,–, most targeting the viral …
dramatically expedited global vaccine development efforts,–, most targeting the viral …
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids
Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To
advance informed vaccine design, it is critical that we understand the cellular dynamics …
advance informed vaccine design, it is critical that we understand the cellular dynamics …
[HTML][HTML] Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals
Vaccine-mediated immunity often relies on the generation of protective antibodies and
memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth …
memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth …
Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology
Evidence suggests that innate and adaptive cellular responses mediate resistance to the
influenza virus and confer protection after vaccination. However, few studies have resolved …
influenza virus and confer protection after vaccination. However, few studies have resolved …