Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof.

EW Martin, AS Holehouse - Emerging topics in life sciences, 2020 - europepmc.org
Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …

Adaptable hydrogel networks with reversible linkages for tissue engineering

H Wang, SC Heilshorn - Advanced Materials, 2015 - Wiley Online Library
Adaptable hydrogels have recently emerged as a promising platform for three‐dimensional
(3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels …

Structural determinants of Smad function in TGF-β signaling

MJ Macias, P Martin-Malpartida, J Massagué - Trends in biochemical …, 2015 - cell.com
Smad transcription factors are central to the signal transduction pathway that mediates the
numerous effects of the transforming growth factor β (TGF-β) superfamily of cytokines in …

Virus budding and the ESCRT pathway

J Votteler, WI Sundquist - Cell host & microbe, 2013 - cell.com
Enveloped viruses escape infected cells by budding through limiting membranes. In the
decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes …

Multicomponent self-assembly as a tool to harness new properties from peptides and proteins in material design

BO Okesola, A Mata - Chemical Society Reviews, 2018 - pubs.rsc.org
Nature is enriched with a wide variety of complex, synergistic, and highly functional protein-
based multicomponent assemblies. As such, nature has served as a source of inspiration for …

Retinoic acid receptors: from molecular mechanisms to cancer therapy

A Di Masi, L Leboffe, E De Marinis, F Pagano… - Molecular aspects of …, 2015 - Elsevier
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Polyproline-II helix in proteins: structure and function

AA Adzhubei, MJE Sternberg, AA Makarov - Journal of molecular biology, 2013 - Elsevier
The poly-l-proline type II (PPII) helix in recent years has emerged clearly as a structural class
not only of fibrillar proteins (in collagen, PPII is a dominant conformation) but also of the …

[HTML][HTML] Invited review: Caseins and the casein micelle: Their biological functions, structures, and behavior in foods

C Holt, JA Carver, H Ecroyd, DC Thorn - Journal of dairy science, 2013 - Elsevier
A typical casein micelle contains thousands of casein molecules, most of which form
thermodynamically stable complexes with nanoclusters of amorphous calcium phosphate …

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

J Huang, S Wu, J Barrera, K Matthews, D Pan - Cell, 2005 - cell.com
Coordination between cell proliferation and cell death is essential to maintain homeostasis
in multicellular organisms. In Drosophila, these two processes are regulated by a pathway …

Epithelial sodium channel (ENaC) family: Phylogeny, structure–function, tissue distribution, and associated inherited diseases

I Hanukoglu, A Hanukoglu - Gene, 2016 - Elsevier
The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …