Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations.
By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic …

Majority of clear cell renal cell carcinomas (ccRCCs) are diagnosed in the advanced
metastatic stage resulting in dramatic decrease of patient survival. Thereby, early detection …

Over the past few years several investigators have independently described unique low-
grade renal epithelial neoplasms with clear cytoplasm, focal to diffuse papillary architecture …

To clarify the significance of DNA methylation alterations during renal carcinogenesis,
methylome analysis using single-CpG-resolution Infinium array was performed on 29 normal …

Loss of chromosome 14 has been associated with poor outcomes in clear-cell renal cell
carcinoma. Expression of HIFα isoforms has been linked to distinct molecular phenotypes of …

Renal cell carcinoma (RCC) is the most common kidney cancer and includes several
molecular and histological subtypes with different clinical characteristics. While survival …

Diagnosis of renal cell carcinoma (RCC) at an early stage is challenging, but it provides the
best chance for cure. We aimed to develop a predictive diagnostic method for early-stage …

Iron overload has been associated with carcinogenesis in humans. Intraperitoneal
administration of ferric nitrilotriacetate initiates a Fenton reaction in renal proximal tubules of …

Significant advances in molecular medicine have made renal cell carcinoma (RCC) the
prototype solid organ malignancy for targeted medical cancer treatment. Theseis new …

Alterations of DNA methylation, which result in chromosomal instability and silencing of
tumor‐related genes, are among the most consistent epigenetic changes observed in …