Gene expression in Kinetoplastids
CE Clayton - Current opinion in microbiology, 2016 - Elsevier
Highlights•Kinetoplastids do not control transcription of individual protein-coding
genes.•mRNAs are made from polycistronic precursors by trans splicing and …
genes.•mRNAs are made from polycistronic precursors by trans splicing and …
Networks of gene expression regulation in Trypanosoma brucei
CE Clayton - Molecular and biochemical parasitology, 2014 - Elsevier
Regulation of gene expression in Kinetoplastids relies mainly on post-transcriptional
mechanisms. Recent high-throughput analyses, combined with mathematical modelling …
mechanisms. Recent high-throughput analyses, combined with mathematical modelling …
PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator
dsRNA-dependent protein kinase R (PKR) is a ubiquitously expressed enzyme well known
for its roles in immune response. Upon binding to viral dsRNA, PKR undergoes …
for its roles in immune response. Upon binding to viral dsRNA, PKR undergoes …
Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors
The parasite Toxoplasma gondii persists in its hosts by converting from replicating
tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that …
tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that …
Proliferation and Differentiation of Trypanosoma cruzi inside Its Vector Have a New Trigger: Redox Status
NP Nogueira, FMS Saraiva, PE Sultano, PRBB Cunha… - PloS one, 2015 - journals.plos.org
Trypanosoma cruzi proliferate and differentiate inside different compartments of triatomines
gut that is the first environment encountered by T. cruzi. Due to its complex life cycle, the …
gut that is the first environment encountered by T. cruzi. Due to its complex life cycle, the …
Amino acid deprivation promotes tumor angiogenesis through the GCN2/ATF4 pathway
Y Wang, Y Ning, GN Alam, BM Jankowski, Z Dong… - Neoplasia, 2013 - Elsevier
As tumors continue to grow and exceed their blood supply, nutrients become limited leading
to deficiencies in amino acids (AAD), glucose (GD), and oxygen (hypoxia). These alterations …
to deficiencies in amino acids (AAD), glucose (GD), and oxygen (hypoxia). These alterations …
PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium
In response to environmental stresses, the mammalian serine threonine kinases PERK,
GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic translation …
GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic translation …
Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in Trypanosoma cruzi
AC Mesías, NJ Garg, MP Zago - Frontiers in Cellular and Infection …, 2019 - frontiersin.org
The toxicity of oxygen and nitrogen reactive species appears to be merely the tip of the
iceberg in the world of redox homeostasis. Now, oxidative stress can be seen as a two-sided …
iceberg in the world of redox homeostasis. Now, oxidative stress can be seen as a two-sided …
Metabolic Reprogramming during Purine Stress in the Protozoan Pathogen Leishmania donovani
The ability of Leishmania to survive in their insect or mammalian host is dependent upon an
ability to sense and adapt to changes in the microenvironment. However, little is known …
ability to sense and adapt to changes in the microenvironment. However, little is known …
Proteome-Wide Analysis of Trypanosoma cruzi Exponential and Stationary Growth Phases Reveals a Subcellular Compartment-Specific Regulation
Trypanosoma cruzi, the etiologic agent of Chagas disease, cycles through different life
stages characterized by defined molecular traits associated with the proliferative or …
stages characterized by defined molecular traits associated with the proliferative or …