SLC38A5/SNAT5 is a system N transporter that can mediate net inward or outward
transmembrane fluxes of neutral amino acids coupled with Na+ (symport) and H+ (antiport) …

Pancreatic ductal adenocarcinoma (PDAC) cells have a great demand for nutrients in the
form of sugars, amino acids, and lipids. Particularly, amino acids are critical for cancer …

Retinopathy of prematurity (ROP) is a primary cause of visual impairment and blindness in
premature newborns, characterized by vascular abnormalities in the develo** retina, with …

Pancreatic cancer is characterized by a poor prognosis, with its five-year survival rate lower
than that of any other cancer type. Gemcitabine, a standard treatment for pancreatic cancer …

Brain L-serine is critical for neurodevelopment and is thought to be synthesized solely from
glucose. In contrast, we found that the influx of L-serine across the blood–brain barrier (BBB) …

After menstruation the uterine spiral arteries are repaired through angiogenesis. This
process is tightly regulated by the paracrine communication between endometrial stromal …

Activation of anaplerosis takes away glutamine from the biosynthetic pathways to the energy-
producing TCA cycle. Especially, induction of hyperoxia driven anaplerosis in neurovascular …

Choroidal neovascularization (CNV) causes acute vision loss in neovascular age-related
macular degeneration (AMD). Genetic variations of the nuclear receptor RAR-related orphan …

Wnt/β-catenin signaling is essential for embryonic eye development in both the anterior eye
and retina. WNT2B, a ligand and activator of the Wnt/β-catenin pathway, assists in the …

Background Mechanical unloading-induced bone loss threatens prolonged spaceflight and
human health. Recent studies have confirmed that osteoporosis is associated with a …