The levels and conformers of alpha‐synuclein are critical in the pathogenesis of Parkinson's
Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation …

The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses.
Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the …

Ubiquitination is a post-translational modification (PTM) that is essential for balancing
numerous physiological processes. To enable delineation of protein ubiquitination at a site …

System-wide quantitative analysis of ubiquitylomes has proven to be a valuable tool for
elucidating targets and mechanisms of the ubiquitin-driven signaling systems, as well as …

Many molecular mechanisms underlie the changes in synaptic glutamate receptor content
that are required by neuronal networks to generate cellular correlates of learning and …

Protein ubiquitylation is involved in a plethora of cellular processes. While antibodies
directed at ubiquitin remnants (K-ɛ-GG) have improved the ability to monitor ubiquitylation …

Ubiquitin signaling is a sequence of events driving the fate of a protein based on the type of
ubiquitin modifications attached. In the case of neurodegenerative diseases, ubiquitin …

Small GTPases of the Rab family not only regulate target recognition in membrane traffic but
also control other cellular functions such as cytoskeletal transport and autophagy. Here we …

In Parkinson's disease, misfolded α-synuclein accumulates, often in a ubiquitinated form, in
neuronal inclusions termed Lewy bodies. An important outstanding question is whether …

While defective α-synuclein homeostasis is central to Parkinson's pathogenesis,
fundamental questions about its degradation remain unresolved. We have developed a …