Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases
Abstract The Ca2+-sensing receptor (CaSR) is a dimeric family CG protein-coupled receptor
that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and …
that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and …
The role of astrocytes in amyloid production and Alzheimer's disease
GR Frost, YM Li - Open biology, 2017 - royalsocietypublishing.org
Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …
Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …
astrocytes participate in several pathophysiological processes including neuroinflammation …
Insights into the pathogenesis of neurodegenerative diseases: Focus on mitochondrial dysfunction and oxidative stress
A Jurcau - International journal of molecular sciences, 2021 - mdpi.com
As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …
intensive research, important steps in the elucidation of pathogenetic cascades have been …
Role of calcium modulation in the pathophysiology and treatment of Alzheimer's disease
D Baracaldo-Santamaría, SS Avendaño-Lopez… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …
cause of progressive dementia in senior adults. It is characterized by memory loss and …
The calcium-sensing receptor in inflammation: Recent updates
The Calcium-Sensing Receptor (CaSR) is a member of the class C of G-proteins coupled
receptors (GPCRs), it plays a pivotal role in calcium homeostasis by directly controlling …
receptors (GPCRs), it plays a pivotal role in calcium homeostasis by directly controlling …
International union of basic and clinical pharmacology. CVIII. Calcium-sensing receptor nomenclature, pharmacology, and function
The calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor that responds
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …
Intracellular calcium dysregulation: implications for Alzheimer's disease
S Magi, P Castaldo, ML Macrì… - BioMed research …, 2016 - Wiley Online Library
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive
neuronal loss. AD is associated with aberrant processing of the amyloid precursor protein …
neuronal loss. AD is associated with aberrant processing of the amyloid precursor protein …
Amyloid β-exposed human astrocytes overproduce phospho-tau and overrelease it within exosomes, effects suppressed by calcilytic NPS 2143—further implications …
A Chiarini, U Armato, E Gardenal, L Gui… - Frontiers in …, 2017 - frontiersin.org
The two main drivers of Alzheimer's disease (AD), amyloid-β (Aβ) and hyperphosphorylated
Tau (p-Tau) oligomers, cooperatively accelerate AD progression, but a hot debate is still …
Tau (p-Tau) oligomers, cooperatively accelerate AD progression, but a hot debate is still …