Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with
tissue-specific transcription factors to regulate development and maintain homeostasis. We …

Aging encompasses a wide array of detrimental effects that compromise physiological
functions, elevate the risk of chronic diseases, and impair cognitive abilities. However, the …

Population-level variation and mechanisms behind insulin secretion in response to
carbohydrate, protein, and fat remain uncharacterized. We defined prototypical insulin …

Background. Type 1 diabetes is an autoimmune disease characterized by T-cell–mediated
destruction of pancreatic beta-cells. Islet transplantation is an effective therapy, but its …

Human embryonic stem cell (hESC)-derived pancreatic α-and β-cells can be used to
develop cell replacement therapies to treat diabetes. However, recent published …

Human embryonic stem cell (hESC)-derived pancreatic alpha and beta cells can be used to
develop cell replacement therapies to treat diabetes. However, recent published …

Pancreatic β cells secrete insulin in response to elevated levels of glucose. Stem cell
derived β (SCβ) cells aim to replicate this glucose-stimulated insulin secretion (GSIS) …

Objective Human embryonic stem cell (hESC; SC)-derived pancreatic β cells can be used to
study diabetes pathologies and develop cell replacement therapies. Although current …

Stem cell-derived β-cells (SCβ-cell) are a renewable and scalable alternative to cadaveric
islets as a cell replacement therapy for type 1 diabetes (T1D). However, heterogeneity within …

Epidemiological studies consistently link environmental toxicant exposure with increased
Type 2 diabetes risk. Our study investigated the diabetogenic effects of a widely used flame …