Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large
oncosomes have been shown to participate in a wide variety of biological processes and are …

The use of polymeric nanocarriers to transport active compounds like small-molecular drugs,
peptides, or genes found an increased attention throughout the different fields of natural …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

The first disulfide linkage-employing drug conjugate that exploits the reversible nature of this
unique covalent bond was recently approved for human use. Increasing numbers of drug …

The prevailing view is that disulfide bonds have been added during evolution to enhance
the stability of proteins that function in a fluctuating cellular environment. However, recent …

Highlights•PDI is an important oxidase, reductase, isomerase and molecular
chaperone.•PDI expression is up-regulated in select types of cancers.•Silencing PDI results …

Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which
catalyze disulfide bonds formation, reduction, or isomerization of newly synthesized proteins …

Thiol proteins may potentially act as redox signaling adaptor proteins, adjusting reactive
oxygen species intermediates to specific signals and redox signals to cell homeostasis. In …

Exploiting the redox-sensitivity of disulfide bonds is an increasingly popular means to trigger
drug release at a target location in the body. The bio-reducible linker (containing a disulfide) …

The considerable length of DNA in eukaryotic genomes requires packaging into chromatin
to fit inside the small dimensions of the cell nucleus. Histone H1 functions in the compaction …