The oral microbiome: Role of key organisms and complex networks in oral health and disease

L Sedghi, V DiMassa, A Harrington… - Periodontology …, 2021 - Wiley Online Library
States of oral health and disease reflect the compositional and functional capacities of, as
well as the interspecies interactions within, the oral microbiota. The oral cavity exists as a …

[HTML][HTML] Periodontal disease: the good, the bad, and the unknown

LM Sedghi, M Bacino, YL Kapila - Frontiers in cellular and infection …, 2021 - frontiersin.org
Periodontal disease is classically characterized by progressive destruction of the soft and
hard tissues of the periodontal complex, mediated by an interplay between dysbiotic …

[HTML][HTML] The oralome and its dysbiosis: New insights into oral microbiome-host interactions

A Radaic, YL Kapila - Computational and structural biotechnology journal, 2021 - Elsevier
The oralome is the summary of the dynamic interactions orchestrated between the
ecological community of oral microorganisms (comprised of up to approximately 1000 …

[HTML][HTML] Mechanism of alveolar bone destruction in periodontitis—Periodontal bacteria and inflammation

M Usui, S Onizuka, T Sato, S Kokabu, W Ariyoshi… - … Dental Science Review, 2021 - Elsevier
Periodontal disease is an inflammatory disease caused by periodontopathogenic bacteria,
which eventually leads to bone tissue (alveolar bone) destruction as inflammation persists …

Periodontal disease–related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: an emerging concept of oral‐liver axis

R Kuraji, S Sekino, Y Kapila, Y Numabe - Periodontology 2000, 2021 - Wiley Online Library
Periodontal disease, a chronic inflammatory disease of the periodontal tissues, is not only a
major cause of tooth loss, but it is also known to exacerbate/be associated with various …

[HTML][HTML] Polymicrobial infections and biofilms: clinical significance and eradication strategies

VT Anju, S Busi, M Imchen, R Kumavath, MS Mohan… - Antibiotics, 2022 - mdpi.com
Biofilms are population of cells growing in a coordinated manner and exhibiting resistance
towards hostile environments. The infections associated with biofilms are difficult to control …

Periodontitis: etiology, conventional treatments, and emerging bacteriophage and predatory bacteria therapies

A Łasica, P Golec, A Laskus, M Zalewska… - Frontiers in …, 2024 - frontiersin.org
Inflammatory periodontal diseases associated with the accumulation of dental biofilm, such
as gingivitis and periodontitis, are very common and pose clinical problems for clinicians …

Molecular basis beyond interrelated bone resorption/regeneration in periodontal diseases: a concise review

KM Sadek, S El Moshy, IA Radwan, D Rady… - International Journal of …, 2023 - mdpi.com
Periodontitis is the sixth most common chronic inflammatory disease, destroying the tissues
supporting the teeth. There are three distinct stages in periodontitis: infection, inflammation …

Paradigm shift in the pathogenesis and treatment of oral cancer and other cancers focused on the oralome and antimicrobial‐based therapeutics

A Radaic, S Ganther, P Kamarajan… - Periodontology …, 2021 - Wiley Online Library
The oral microbiome is a community of microorganisms, comprised of bacteria, fungi,
viruses, archaea, and protozoa, that form a complex ecosystem within the oral cavity …

Relationship of Porphyromonas gingivalis and Alzheimer's disease: a systematic review of pre-clinical studies

MJF Costa, IDT de Araújo, L da Rocha Alves… - Clinical oral …, 2021 - Springer
Objectives This study aimed to analyze the following PICO question: Are animals infected
with Porphyromonas gingivalis (P. gingivalis) or bacterial lipopolysaccharide (Pg-LPS) more …