TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of
the respiratory and gastrointestinal tract, the prostate, and other organs. Although the …

Of huge importance now is to provide a fast, cost-effective, safe, and immediately available
pharmaceutical solution to curb the rapid global spread of SARS-CoV-2. Recent …

The novel emerged SARS-CoV-2 has rapidly spread around the world causing acute
infection of the respiratory tract (COVID-19) that can result in severe disease and lethality …

Abstract Coronavirus disease 2019 (COVID-19) initiated in December 2019 in Wuhan,
China and became pandemic causing high fatality and disrupted normal life calling world …

Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is essential for virus
infectivity and spread. We previously demonstrated in vitro that the transmembrane protease …

Influenza is an acute infection of the respiratory tract, which affects each year millions of
people. Influenza virus infection is initiated by the surface glycoprotein hemagglutinin (HA) …

Highlights•Influenza virus replication depends on activation by airway proteases of the
host.•One prominent enzyme, TMPRSS2, also activates some other respiratory …

Cleavage of the hemagglutinin (HA) by host proteases is essential for the infectivity of
influenza viruses. Here, we analyzed the role of the serine protease TMPRSS2, which …

The hemagglutinin (HA) is a prime determinant of the pathogenicity of influenza A viruses. It
initiates infection by binding to cell surface receptors and by inducing membrane fusion. The …

Cellular proteases are reponsible for activation of influenza virus hemagglutinin (HA) in
epithelial tissues of the respiratory tract. The trans-Golgi network (TGN) is the main …