▪ Abstract Systems biology studies biological systems by systematically perturbing them
(biologically, genetically, or chemically); monitoring the gene, protein, and informational …

Electron microscopic (EM) tomography is providing important new insights into the internal
organization of mitochondria. The standard baffle model for cristae structure, called into …

YAP/TAZ is a master regulator of mechanotransduction whose functions rely on
translocation from the cytoplasm to the nucleus in response to diverse physical cues …

The MAPK (mitogen-activated protein kinase) pathway is one of the most important and
intensively studied signalling pathways. It is at the heart of a molecular-signalling network …

Carbapenems are antibiotics of last resort in the clinic. Owing to their potency and broad-
spectrum activity, they are an important part of the antibiotic arsenal. The vital role of …

Environmental impacts by both natural events and man-made interventions are a fact of life;
and develo** the capacity to minimise these impacts and their harmful consequences for …

The newly emerging field of computational cell biology requires software tools that address
the needs of a broad community of scientists. Cell biological processes are controlled by an …

Complex biochemical networks can be understood by identifying their principal regulatory
motifs and mode of action. We model the early phase of budding yeast cellular polarization …

Study of the cell will never be complete unless its dynamic behavior is understood. The
complex behavior of the cell cannot be determined or predicted unless a computer model of …

This review summarizes recent findings from electron tomography about the three-
dimensional shape of mitochondrial membranes and its possible influence on a range of …