Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …

The function of Fanconi anaemia proteins is to maintain genomic stability. Their main role is
in the repair of DNA interstrand crosslinks, which, by covalently binding the Watson and the …

DNA repair deficiency can lead to segmental phenotypes in humans and mice, in which
certain tissues lose homeostasis while others remain seemingly unaffected. This may be …

Fanconi Anemia (FA) is an inherited genomic instability disorder, caused by mutations in
genes regulating replication-dependent removal of interstrand DNA crosslinks. The Fanconi …

DNA interstrand cross-links (ICLs) are lesions caused by a variety of endogenous
metabolites, environmental exposures, and cancer chemotherapeutic agents that have two …

The maintenance of genome stability is critical for survival, and its failure is often associated
with tumorigenesis. The Fanconi anemia (FA) pathway is essential for the repair of DNA …

Fanconi anemia (FA) is a rare genetic disorder associated with a high frequency of
hematological abnormalities and congenital anomalies. Based on multilateral efforts from …

Exposure to arsenic in contaminated drinking water is an emerging public health problem
that impacts more than 200 million people worldwide. Accumulating lines of evidence from …

DNA interstrand crosslinks (ICLs) are highly toxic because they block the progression of
replisomes. The Fanconi Anemia (FA) proteins, encoded by genes that are mutated in FA …

Congenital nucleotide excision repair (NER) deficiency gives rise to several cancer-prone
and/or progeroid disorders. It is not understood how defects in the same DNA repair …