The Wnt/β-catenin signaling pathway has been implicated as the central mechanism that
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …

The WNT/β-catenin is among one of the most extensively studied cellular signaling
pathways involved in the initiation and progression of several deadly cancers. It is now …

Metabolic reprogramming is associated with resistance to antiangiogenic therapy in cancer.
However, its molecular mechanisms have not been clearly elucidated. Here, we identify the …

Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a
central role in the progression of various cancers. The cellular factors that participate in the …

Renal interstitial fibrosis is the common pathological process of various chronic kidney
diseases to end-stage renal disease. Inhibition of fibroblast activation attenuates renal …

Dear Editor, Skeletal aging is characterized by progressive bone loss and increased marrow
adiposity. 1, 2 Age-related bone loss impairs the exercise activity of patients and increases …

Colorectal cancer (CRC) develops in part through the deregulation of different signaling
pathways, including activation of the WNT/β-catenin and PI3K/AKT pathways. Additionally …

BRAF-driven colorectal cancer is among the poorest prognosis subtypes of colon cancer.
Previous studies suggest that BRAF-mutant serrated cancers frequently exhibit Microsatellite …

Gastric cancer (GC) is one of the most prevalent malignancies and the most common causes
of cancer-related mortality worldwide. Furthermore, the prognosis of advanced GC remains …

Chemoresistance is a major obstacle to the treatment of triple‐negative breast cancer
(TNBC), which has a poor prognosis. Increasing evidence has demonstrated the essential …