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Neuropathology and molecular diagnosis of Synucleinopathies
Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …
The expanding amyloid family: Structure, stability, function, and pathogenesis
The hidden world of amyloid biology has suddenly snapped into atomic-level focus,
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
Structures of α-synuclein filaments from human brains with Lewy pathology
Parkinson's disease (PD) is the most common movement disorder, with resting tremor,
rigidity, bradykinesia and postural instability being major symptoms. Neuropathologically, it …
rigidity, bradykinesia and postural instability being major symptoms. Neuropathologically, it …
Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy
Synucleinopathies are neurodegenerative diseases that are associated with the misfolding
and aggregation of α-synuclein, including Parkinson's disease, dementia with Lewy bodies …
and aggregation of α-synuclein, including Parkinson's disease, dementia with Lewy bodies …
Protein transmission in neurodegenerative disease
Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …
Structures of α-synuclein filaments from multiple system atrophy
Synucleinopathies, which include multiple system atrophy (MSA), Parkinson's disease,
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …
Glutathione in brain disorders and aging
Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …
Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies
The clinical diagnosis of synucleinopathies, including Parkinson's disease (PD), dementia
with Lewy bodies (DLB), and multiple system atrophy (MSA), is challenging, especially at an …
with Lewy bodies (DLB), and multiple system atrophy (MSA), is challenging, especially at an …
Meta‐analysis of gut dysbiosis in Parkinson's disease
Background PD may begin with the intestinal accumulation of α‐synuclein fibrils, which can
be causally associated with gut dysbiosis. The variability of gut microbiota across countries …
be causally associated with gut dysbiosis. The variability of gut microbiota across countries …