The hidden world of amyloid biology has suddenly snapped into atomic-level focus,
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …

Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

Parkinson's disease (PD) is the most common movement disorder, with resting tremor,
rigidity, bradykinesia and postural instability being major symptoms. Neuropathologically, it …

Synucleinopathies are neurodegenerative diseases that are associated with the misfolding
and aggregation of α-synuclein, including Parkinson's disease, dementia with Lewy bodies …

Synucleinopathies, which include multiple system atrophy (MSA), Parkinson's disease,
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …

Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …

A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

Abstract α-Synuclein (aSyn) fibrillar polymorphs have distinct in vitro and in vivo seeding
activities, contributing differently to synucleinopathies. Despite numerous prior attempts, how …

The self-assembly of α-synuclein (αS) into intraneuronal inclusion bodies is a key
characteristic of Parkinson's disease. To define the nature of the species giving rise to …

Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …