Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …

Inactivation of the transcription factor p53, through either direct mutation or aberrations in
one of its many regulatory pathways, is a hallmark of virtually every tumor. In recent years …

Almost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource
remains an invaluable source of information for the study of motif-mediated protein-protein …

In the hit identification stage of drug discovery, a diverse chemical space needs to be
explored to identify initial hits. Contrary to empirical scoring functions, absolute protein …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …

Protein intrinsic disorder is becoming increasingly recognized in proteomics research. While
lacking structure, many regions of disorder have been associated with biological function …

The tumor suppressor protein p53 induces or represses the expression of a variety of target
genes involved in cell cycle control, senescence, and apoptosis in response to oncogenic or …

Several proteomic studies in the last decade revealed that many proteins are either
completely disordered or possess long structurally flexible regions. Many such regions were …

Even 30 years after its discovery, the tumor suppressor protein p53 is still somewhat of an
enigma. p53's intimate and multifaceted role in the cell cycle is mirrored in its equally …