Abstract β-Hydroxybutyrate (βOHB), a ketone body, is oxidised as a brain fuel. Although its
contribution to energy metabolism in the healthy brain is minimal, it is an interesting …

Abstract γ-Hydroxybutyric acid (GHB) is an endogenous compound in the mammalian brain
with both low-and high-affinity receptor targets. GHB is used clinically in the treatment of …

Metabolomics has been widely applied to toxicological fields, especially to elucidate the
mechanism of action of toxicity. In this review, metabolomics application with focus on the …

γ-Hydroxybutyric acid (GHB) binding to brain-specific high-affinity sites is well-established
and proposed to explain both physiological and pharmacological actions. However, the …

Abstract Objective: γ-Hydroxybutyrate (GHB) has gained popularity as a drug of abuse. In
the Netherlands the number of patients in treatment for GHB dependence has increased …

Emerging evidence indicates the role of amino acid metabolism in sleep regulation. Here we
demonstrate sleep-promoting effects of dietary threonine (SPET) in Drosophila. Dietary …

Abstract L-Ornithine-L-aspartate (LOLA), a crystalline salt, is used primarily in the
management of hepatic encephalopathy. The degree to which it might penetrate the brain …

Gamma‐hydroxybutyrate (GHB) is a short‐chain fatty acid that occurs naturally in the
mammalian brain and is prescribed as a medication against narcolepsy or used as a drug of …

We have previously observed that the conversion of mild cognitive impairment to definitive
Alzheimer's disease (AD) is associated with a significant increase in the serum level of 2, 4 …

Abstract [13C] Acetate is known to label metabolites preferentially in astrocytes rather than
neurons and it has consequently been used as a marker for astrocytic activity. Recent …