Dysbiosis and the immune system
Throughout the past century, we have seen the emergence of a large number of
multifactorial diseases, including inflammatory, autoimmune, metabolic, neoplastic and …
multifactorial diseases, including inflammatory, autoimmune, metabolic, neoplastic and …
The microbiome and cancer
Microbiota and host form a complex'super-organism'in which symbiotic relationships confer
benefits to the host in many key aspects of life. However, defects in the regulatory circuits of …
benefits to the host in many key aspects of life. However, defects in the regulatory circuits of …
Potential roles of gut microbiome and metabolites in modulating ALS in mice
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder, in which the
clinical manifestations may be influenced by genetic and unknown environmental factors …
clinical manifestations may be influenced by genetic and unknown environmental factors …
[HTML][HTML] NOD1 and NOD2: signaling, host defense, and inflammatory disease
The nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2, the
founding members of the intracellular NOD-like receptor family, sense conserved motifs in …
founding members of the intracellular NOD-like receptor family, sense conserved motifs in …
Peptidoglycan recognition by the innate immune system
AJ Wolf, DM Underhill - Nature Reviews Immunology, 2018 - nature.com
The innate immune system recognizes microbial products using germline-encoded
receptors that initiate inflammatory responses to infection. The bacterial cell wall component …
receptors that initiate inflammatory responses to infection. The bacterial cell wall component …
NOD proteins: regulators of inflammation in health and disease
Entry of bacteria into host cells is an important virulence mechanism. Through peptidoglycan
recognition, the nucleotide-binding oligomerization domain (NOD) proteins NOD1 and …
recognition, the nucleotide-binding oligomerization domain (NOD) proteins NOD1 and …
Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity
The intestinal epithelium forms a barrier between the microbiota and the rest of the body. In
addition, beyond acting as a physical barrier, the function of intestinal epithelial cells (IEC s) …
addition, beyond acting as a physical barrier, the function of intestinal epithelial cells (IEC s) …
Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design
Targeted manipulation of the gut flora is increasingly being recognized as a means to
improve human health. Yet, the temporal dynamics and intra-and interindividual …
improve human health. Yet, the temporal dynamics and intra-and interindividual …
No vacancy: how beneficial microbes cooperate with immunity to provide colonization resistance to pathogens
M Sassone-Corsi, M Raffatellu - The Journal of Immunology, 2015 - journals.aai.org
The mammalian intestine harbors a community of trillions of microbes, collectively known as
the gut microbiota, which coevolved with the host in a mutually beneficial relationship …
the gut microbiota, which coevolved with the host in a mutually beneficial relationship …
Immune–microbiota interactions in health and disease
Recent studies have revealed that the intestinal microbiota plays an important role in host
physiology and pathophysiology in health and disease. One of the major mechanisms by …
physiology and pathophysiology in health and disease. One of the major mechanisms by …