Spatial multiplexing and omics
Much like solving a game of Clue, understanding physiological mysteries involves
answering who, what, when and where. Multiomics approaches delve into cellular and …
answering who, what, when and where. Multiomics approaches delve into cellular and …
Small animal PET: a review of what we have done and where we are going
Small animal research is an essential tool in studying both pharmaceutical biodistribution
and disease progression over time. Furthermore, through the rapid development of in vivo …
and disease progression over time. Furthermore, through the rapid development of in vivo …
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease
B Zeitler, S Froelich, K Marlen, DA Shivak, Q Yu, D Li… - Nature medicine, 2019 - nature.com
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic …
a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic …
Performance evaluation of the MOLECUBES β-CUBE—a high spatial resolution and high sensitivity small animal PET scanner utilizing monolithic LYSO scintillation …
S Krishnamoorthy, E Blankemeyer… - Physics in Medicine …, 2018 - iopscience.iop.org
The MOLECUBES β-CUBE scanner is the newest amongst commercially available
preclinical PET scanners for dedicated small animal imaging. The scanner is compact …
preclinical PET scanners for dedicated small animal imaging. The scanner is compact …
Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study
Purpose Pathological studies suggest that neuroinflammation is exacerbated by increased
beta-amyloid (Aβ) levels in the brain early in Alzheimer's disease (AD). The time course and …
beta-amyloid (Aβ) levels in the brain early in Alzheimer's disease (AD). The time course and …
A prototype high-resolution small-animal PET scanner dedicated to mouse brain imaging
We developed a prototype small-animal PET scanner based on depth-encoding detectors
using dual-ended readout of small scintillator elements to produce high and uniform spatial …
using dual-ended readout of small scintillator elements to produce high and uniform spatial …
DigiPET: sub-millimeter spatial resolution small-animal PET imaging using thin monolithic scintillators
A new preclinical PET system based on dSiPMs, called DigiPET, is presented. The system is
based on thin monolithic scintillation crystals and exhibits superior spatial resolution at low …
based on thin monolithic scintillation crystals and exhibits superior spatial resolution at low …
Preclinical imaging: an essential ally in modern biosciences
L Cunha, I Horvath, S Ferreira, J Lemos… - Molecular diagnosis & …, 2014 - Springer
Translational research is changing the practice of modern medicine and the way in which
health problems are approached and solved. The use of small-animal models in basic and …
health problems are approached and solved. The use of small-animal models in basic and …
[HTML][HTML] Different effects of CYP27A1 and CYP7B1 on cognitive function: two mouse models in comparison
J Goikolea, M Latorre-Leal, C Tsagkogianni… - The Journal of steroid …, 2023 - Elsevier
Abstract The oxysterol 27-hydroxycholesterol (27OHC) is produced by the enzyme sterol 27-
hydroxylase (Cyp27A1) and is mainly catabolized to 7α-Hydroxy-3-oxo-4-cholestenoic acid …
hydroxylase (Cyp27A1) and is mainly catabolized to 7α-Hydroxy-3-oxo-4-cholestenoic acid …
Performance evaluation of the small-animal nanoScan PET/MRI system
K Nagy, M Tóth, P Major, G Patay, G Egri… - Journal of Nuclear …, 2013 - Soc Nuclear Med
nanoScan is a high-resolution integrated system for consecutive PET and MR imaging of
small laboratory animals. We evaluated the performance of the system, using the NEMA NU …
small laboratory animals. We evaluated the performance of the system, using the NEMA NU …