Clinical translation of nanomedicines: Challenges, opportunities, and keys

MA Younis, HM Tawfeek, AAH Abdellatif… - Advanced drug delivery …, 2022 - Elsevier
Despite the massive interest and recent developments in the field of nanomedicine, only a
limited number of formulations have found their way to the clinics. This shortcoming reveals …

Lipid nanoparticles technology in vaccines: Sha** the future of prophylactic medicine

AAH Abdellatif, MA Younis, AF Alsowinea… - Colloids and Surfaces B …, 2023 - Elsevier
Throughout decades, the intrinsic power of the immune system to fight pathogens has
inspired researchers to develop techniques that enable the prevention or treatment of …

Chitosan-capped silver nanoparticles with potent and selective intrinsic activity against the breast cancer cells

AAH Abdellatif, A Abdelfattah, MA Younis… - Nanotechnology …, 2023 - degruyter.com
Herein, we report on the development of chitosan-capped silver nanoparticles (AgNPs-CHI)
with an intrinsic activity against breast cancer cells. Following chemical synthesis via a …

Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic applications

H Zhang, Y **, C Chi, G Han, W Jiang, Z Wang… - Biomaterials, 2021 - Elsevier
Sponge particulates have attracted enormous attention in biomedical applications for
superior properties, including large porosity, elastic deformation, capillary action, and three …

[HTML][HTML] Development of apigenin loaded gastroretentive microsponge for the targeting of Helicobacter pylori

M Jafar, MSA Khan, M Salahuddin, S Zahoor… - Saudi Pharmaceutical …, 2023 - Elsevier
The goal of the present work was to invent an apigenin-stacked gastroretentive microsponge
to target H. pylori. The quasi-emulsion technique was used to prepare microsponges, which …

Polymeric microsponges: an emerging prospect in topical delivery of therapeutic agents

L Kumar, M Chadha, R Rana, G Kukreti… - … Journal of Polymeric …, 2024 - Taylor & Francis
Skin disorders have an important psychosocial impact on the life of the affected patient. Skin
disorders are usually treated by using topical drug delivery systems like creams and gels …

Preparation and In Vitro-In Vivo Evaluation of Luteolin Loaded Gastroretentive Microsponge for the Eradication of Helicobacter pylori Infections

M Jafar, M Salahuddin, MSA Khan, Y Alshehry… - Pharmaceutics, 2021 - mdpi.com
The current study aimed to develop a luteolin gastric floating microsponge for targeting
Helicobacter pylori. The microsponge formulations were prepared by a quasi-emulsion …

[HTML][HTML] Thiolated chitosan microneedle patch of levosulpiride from fabrication, characterization to bioavailability enhancement approach

R Habib, AK Azad, M Akhlaq, FA Al-Joufi, G Shahnaz… - Polymers, 2022 - mdpi.com
In this study, a first attempt has been made to deliver levosulpiride transdermally through a
thiolated chitosan microneedle patch (TC-MNP). Levosulpiride is slowly and weakly …

Adapted nano-carriers for gastrointestinal defense components: surface strategies and challenges

W Wang, X Yan, Q Li, Z Chen, Z Wang, H Hu - … , Biology and Medicine, 2020 - Elsevier
Nano-carriers (NCs) provide drugs with protective and oriented strategies. Despite their
success in parenteral administration, NCs still need to be optimized to meet the more …

Intranasal delivery of sulpiride nanostructured lipid carrier to central nervous system; in vitro characterization and in vivo study

HM Tawfeek, AI Mekkawy, AAH Abdelatif… - Pharmaceutical …, 2024 - Taylor & Francis
The low and erratic oral absorption of sulpiride (SUL) a dopaminergic receptor antagonist,
and its P-glycoprotein efflux in the gastrointestinal tract restricted its oral route for central …