Most enzyme modification strategies focus on designing the active sites or their surrounding
structures. Interestingly, a large portion of the enzymes (60%) feature active sites located …

Microbes typically live in complex habitats, where they need to rapidly adapt to continuously
changing growth conditions. To do so, they produce an astonishing array of natural products …

A linear, three-ring phenolic compound containing a free radical reported pharmacological
effects against the anti-tuberculosis (TB) disease. In our study, psoralidin, or 3, 9-dihydroxy-2 …

Salmonella enterica serovar Typhi spreads typhoid infection in humans through the
consumption of contaminated food and water. Poor sanitation plays a pivotal role in its …

Dengue virus is a single positive-strand RNA virus that is composed of three structural
proteins including capsid, envelope, and precursor membrane while seven non-structural …

Talaromyces marneffei is a thermally dimorphic fungus that can cause life-threatening
systemic mycoses, particularly in immunocompromised individuals. Fungal homeobox …

The limitations of the current vaccination strategy for the Kyasanur Forest Disease virus
(KFDV) underscore the critical need for effective antiviral treatments, highlighting the crucial …

Abstract Brazilian Red Propolis (BRP) is a natural product known for its rich chemical
composition and therapeutic potential. This study investigates the phytochemical profile and …

Malaria remains a global health concern, with the emergence of resistance to the
antimalarial drug atovaquone through cytochrome b (cyt b) being well-documented. This …

Reports of resistance to current antimalarial combination therapies (ACTs) have
necessitated the discovery of new antimalarial drugs, most importantly with new …