Therapeutic potential and challenges of natural killer cells in treatment of solid tumors
A Gras Navarro, AT Björklund, M Chekenya - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …
Signalling via integrins: implications for cell survival and anticancer strategies
S Hehlgans, M Haase, N Cordes - … et Biophysica Acta (BBA)-Reviews on …, 2007 - Elsevier
Integrin-associated signalling renders cells more resistant to genotoxic anti-cancer agents
like ionizing radiation and chemotherapeutic substances, a phenomenon termed cell …
like ionizing radiation and chemotherapeutic substances, a phenomenon termed cell …
Cancer statistics, 2006
Abstract Each year, the American Cancer Society estimates the number of new cancer cases
and deaths expected in the United States in the current year and compiles the most recent …
and deaths expected in the United States in the current year and compiles the most recent …
Chemoradiotherapy with or without cetuximab in patients with oesophageal cancer (SCOPE1): a multicentre, phase 2/3 randomised trial
T Crosby, CN Hurt, S Falk, S Gollins… - The lancet …, 2013 - thelancet.com
Background Definitive chemoradiotherapy (CRT) is an alternative to surgery for the curative
treatment of oesophageal carcinoma. The SCOPE1 trial aimed to investigate the addition of …
treatment of oesophageal carcinoma. The SCOPE1 trial aimed to investigate the addition of …
Cetuximab: an epidermal growth factor receptor chemeric human-murine monoclonal antibody.
J Harding, B Burtness - Drugs of today (Barcelona, Spain: 1998), 2005 - europepmc.org
The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptors. It
is composed of extracellular domains, including a ligand-binding domain, a hydrophobic …
is composed of extracellular domains, including a ligand-binding domain, a hydrophobic …
Targeted therapy of cancer: new prospects for antibodies and immunoconjugates
RM Sharkey, DM Goldenberg - CA: a cancer journal for …, 2006 - Wiley Online Library
ABSTRACT Immunotherapy of cancer has been explored for over a century, but it is only in
the last decade that various antibody‐based products have been introduced into the …
the last decade that various antibody‐based products have been introduced into the …
Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity
K Dittmann, C Mayer, HP Rodemann - Radiotherapy and Oncology, 2005 - Elsevier
BACKGROUND AND PURPOSE: Inhibition of EGFR-function can induce radiosensitization
in tumor cells. Purpose of our investigation was to identify the possible molecular …
in tumor cells. Purpose of our investigation was to identify the possible molecular …
Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agents
DA Reardon, PY Wen - The oncologist, 2006 - academic.oup.com
Learning Objectives After completing this course, the reader will be able to: Describe the
genetic alterations frequently observed in GBM tumors as well as the cell signal transduction …
genetic alterations frequently observed in GBM tumors as well as the cell signal transduction …
The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications
M Zimmermann, A Zouhair, D Azria, M Ozsahin - Radiation oncology, 2006 - Springer
Epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptors. Its
stimulation by endogenous ligands, EGF or transforming growth factor-alpha (TGF-α) results …
stimulation by endogenous ligands, EGF or transforming growth factor-alpha (TGF-α) results …
Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by …
M Toulany, U Kasten-Pisula, I Brammer, S Wang… - Clinical Cancer …, 2006 - AACR
Purpose: It is known that blockage of epidermal growth factor receptor (EGFR)/
phosphatidylinositol 3-kinase (PI3K) activity enhances radiation sensitivity of human tumor …
phosphatidylinositol 3-kinase (PI3K) activity enhances radiation sensitivity of human tumor …