The menopause transition: signs, symptoms, and management options
Context Menopause, the permanent cessation of menses, reflects oocyte depletion and loss
of gonadal steroids. It is preceded by a transition state, the perimenopause, which is …
of gonadal steroids. It is preceded by a transition state, the perimenopause, which is …
Treating menopause—MHT and beyond
Every woman who lives past midlife will experience menopause, which, by definition, is
complete cessation of ovarian function. This process might occur spontaneously (natural …
complete cessation of ovarian function. This process might occur spontaneously (natural …
Drug repurposing: progress, challenges and recommendations
Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is …
development, repurposing of'old'drugs to treat both common and rare diseases is …
Management of menopause: a view towards prevention
Women spend approximately one-third of their lives with menopause, which occurs around
50 years of age. It is now appreciated that several important metabolic and cardiovascular …
50 years of age. It is now appreciated that several important metabolic and cardiovascular …
KNDy cells revisited
In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …
[HTML][HTML] A phase 2b, randomized, placebo-controlled, double-blind, dose-ranging study of the neurokinin 3 receptor antagonist fezolinetant for vasomotor symptoms …
GL Fraser, S Lederman, A Waldbaum, R Kroll… - Menopause, 2020 - journals.lww.com
Objective: Menopausal vasomotor symptoms (VMS) may result from altered
thermoregulatory control in brain regions innervated by neurokinin 3 receptor-expressing …
thermoregulatory control in brain regions innervated by neurokinin 3 receptor-expressing …
Treatment of menopausal vasomotor symptoms with fezolinetant, a neurokinin 3 receptor antagonist: a phase 2a trial
Context The thermoregulatory center in the hypothalamus is stimulated by neurokinin 3
receptor (NK3R) activation and inhibited by estrogen-negative feedback. This balance is …
receptor (NK3R) activation and inhibited by estrogen-negative feedback. This balance is …
[HTML][HTML] Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial
Background Hot flushes affect 70% of menopausal women and often severely impact
physical, psychosocial, sexual, and overall wellbeing. Hormone replacement therapy is …
physical, psychosocial, sexual, and overall wellbeing. Hormone replacement therapy is …
Mechanisms in endocrinology: estradiol as a male hormone
Evidence has been accumulating that, in men, some of the biological actions traditionally
attributed to testosterone acting via the androgen receptor may in fact be dependent on its …
attributed to testosterone acting via the androgen receptor may in fact be dependent on its …
The emerging therapeutic potential of kisspeptin and neurokinin B
B Patel, K Koysombat, EG Mills, J Tsoutsouki… - Endocrine …, 2024 - academic.oup.com
Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …