Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …

Gene set analysis methods are widely used to provide insight into high-throughput gene
expression data. There are many gene set analysis methods available. These methods rely …

The mammalian kidney relies on abundant mitochondria in the renal tubule to generate
sufficient ATP to provide the energy required for constant reclamation of solutes from crude …

Microproteins (MPs) are a potentially rich source of uncharacterized metabolic regulators.
Here, we use ribosome profiling (Ribo-seq) to curate 3,877 unannotated MP-encoding small …

The organs and metabolic pathways involved in energy metabolism, and the process of ATP
production from nutrients, are comparable between humans and Drosophila melanogaster …

In addition to canonical open reading frames (ORFs), thousands of translated small ORFs
(containing less than 100 codons) have been identified in untranslated mRNA regions …

Podocytes are a crucial cellular component in maintaining the glomerular filtration barrier,
and their injury is the major determinant in the development of albuminuria and diabetic …

Physical training is a potent therapeutic approach for improving mitochondrial health
through peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) …

Translation of upstream open reading frames (uORFs) typically abrogates translation of
main (m) ORFs. The molecular mechanism of uORF regulation in cells is not well …