Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

2-Oxoglutarate (2OG) dependent oxygenases are ubiquitous iron enzymes that couple
substrate oxidation to the conversion of 2OG to succinate and carbon dioxide. In humans …

Phosphorescent transition metal complexes have been intensively investigated, since these
luminophores are distinctively different from fluorescent chromophores in terms of the nature …

The pharmacological inhibition of general transcriptional regulators has the potential to
block growth through targeting multiple tumorigenic signalling pathways simultaneously …

The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

Chronic kidney disease (CKD) affects approximately 10% of the worldwide population;
anaemia is a frequent complication. Inadequate erythropoietin production and absolute or …

There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with
small molecules both for the generation of probes for target exploration and for therapeutic …