Over the last decade, liquid biopsy has gained much attention as a powerful tool in
personalized medicine, since it enables monitoring cancer evolution and follow-up of cancer …

Abstract The CellSearch® system (CS) enables standardized enrichment and enumeration
of circulating tumor cells (CTCs) that are repeatedly assessable via non-invasive “liquid …

The cancer stem cell (CSC) model defines tumors as hierarchically organized entities,
containing a small population of tumorigenic CSC, or tumour-initiating cells, placed at the …

Metastasis is the main cause of tumor-related death, and the dispersal of tumor cells through
the circulatory system is a critical step in the metastatic process. Early detection and analysis …

Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein expressed in
epithelial tissues. EpCAM forms intercellular, homophilic adhesions, modulates epithelial …

Background Assuming that tumor cell dissemination requires a shift to a mesenchymal
phenotype, we analyzed the incidence of epithelial-to-mesenchymal-transition (EMT)-like …

(1) Background: The aim of the study was to evaluate the prognostic significance of EMT-
associated (TWIST1) and stem-cell (SC) transcript (CD24, CD44, ALDH1) quantification in …

BACKGROUND Liquid biopsies are discussed to provide surrogate markers for therapy
stratification and monitoring. We compared messenger RNA (mRNA) profiles of circulating …

BACKGROUND Circulating tumor cells (CTCs) are thought to be an ideal surrogate marker
to monitor disease progression in metastatic breast cancer (MBC). We investigated the …

Background We recently showed that the presence of ERCC1+ CTCs is an independent
predictive biomarker for platinum-resistance and poor prognosis of ovarian cancer. The goal …