Cellular and molecular mechanisms involved in hematopoietic stem cell aging as a clinical prospect
There is a hot topic in stem cell research to investigate the process of hematopoietic stem
cell (HSC) aging characterized by decreased self‐renewal ability, myeloid‐biased …
cell (HSC) aging characterized by decreased self‐renewal ability, myeloid‐biased …
Circular RNAs in hematopoiesis with a focus on acute myeloid leukemia and myelodysplastic syndrome
M Dostalova Merkerova, Z Krejcik, K Szikszai… - International Journal of …, 2020 - mdpi.com
Circular RNAs (circRNAs) constitute a recently recognized group of noncoding transcripts
that function as posttranscriptional regulators of gene expression at a new level. Recent …
that function as posttranscriptional regulators of gene expression at a new level. Recent …
Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1
I Trsova, A Hrustincova, Z Krejcik, D Kundrat… - Molecular …, 2023 - Wiley Online Library
Mutations in the splicing factor 3b subunit 1 (SF3B1) gene are frequent in myelodysplastic
neoplasms (MDS). Because the splicing process is involved in the production of circular …
neoplasms (MDS). Because the splicing process is involved in the production of circular …
Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesis
T Božić, J Frobel, A Raic, F Ticconi… - Life science …, 2018 - life-science-alliance.org
De novo DNA methyltransferase 3A (DNMT3A) plays pivotal roles in hematopoietic
differentiation. In this study, we followed the hypothesis that alternative splicing of DNMT3A …
differentiation. In this study, we followed the hypothesis that alternative splicing of DNMT3A …
Using Tumour Evolution to Understand the Epigenetic and Transcriptional Adaptations of Cancer to Host Immunity
T Baird - 2024 - repository.cam.ac.uk
Immunoediting describes the process in tumour development whereby tumours evolve to
avoid the immune system. The relevance of immunoediting in carcinogenesis, metastasis …
avoid the immune system. The relevance of immunoediting in carcinogenesis, metastasis …
[PDF][PDF] DNMT3A splice variants and DNA methylation in normal and malignant hematopoiesis
T Božić - 2019 - scholar.archive.org
DNA methylation (DNAm) is an epigenetic process that guides development and cellular
differentiation. Particularly the de novo DNA methyltransferase 3A (DNMT3A) plays a pivotal …
differentiation. Particularly the de novo DNA methyltransferase 3A (DNMT3A) plays a pivotal …
Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoietic differentiation
The de novo DNA methyltransferase 3A (DNMT3A) plays pivotal roles in hematopoietic
differentiation. In this study, we followed the hypothesis that alternative splicing of DNMT3A …
differentiation. In this study, we followed the hypothesis that alternative splicing of DNMT3A …