Biologically modified nanoparticles as theranostic bionanomaterials
Inspired by natural biology, cell membrane-mimetic surface engineering and cell membrane
camouflaging technology have been widely investigated. Notably, the cell membrane …
camouflaging technology have been widely investigated. Notably, the cell membrane …
[HTML][HTML] Immunotherapy for colorectal cancer
The incidence of colorectal cancer (CRC) is on the rise, and the prognosis for patients with
recurrent or metastatic disease is extremely poor. Although chemotherapy and radiation …
recurrent or metastatic disease is extremely poor. Although chemotherapy and radiation …
Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment
Despite multiple immunotherapeutic technologies that achieve potent T cell activation,
effector T cells still lack efficiency because of the highly immunosuppressive conditions in …
effector T cells still lack efficiency because of the highly immunosuppressive conditions in …
Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells
Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using
exogenous antigens and adoptive cells, we show a concept of utilizing biologically …
exogenous antigens and adoptive cells, we show a concept of utilizing biologically …
Expandable immunotherapeutic nanoplatforms engineered from cytomembranes of hybrid cells derived from cancer and dendritic cells
Using the cytomembranes (FMs) of hybrid cells acquired from the fusion of cancer and
dendritic cells (DCs), this study offers a biologically derived platform for the combination of …
dendritic cells (DCs), this study offers a biologically derived platform for the combination of …
Dendritic cells: unique leukocyte populations which control the primary immune response
DNJ Hart - Blood, The Journal of the American Society of …, 1997 - ashpublications.org
It is now possible to grow DC-like cells in culture17-21 and extensive cell membrane
processes that are acquired late the first monoclonal antibodies (MoAbs) 22, 23 that react …
processes that are acquired late the first monoclonal antibodies (MoAbs) 22, 23 that react …
MUC1, the renaissance molecule
SJ Gendler - Journal of mammary gland biology and neoplasia, 2001 - Springer
MUC1 is a large, heavily glycosylated mucin expressed on the apical surfaces of most
simple, secretory epithelia including the mammary gland, gastrointestinal, respiratory …
simple, secretory epithelia including the mammary gland, gastrointestinal, respiratory …
Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses
Abstract Purpose: Dendritic cells (DCs) are potent antigen-presenting cells that are uniquely
capable of inducing tumor-specific immune responses. We have conducted a Phase I trial in …
capable of inducing tumor-specific immune responses. We have conducted a Phase I trial in …
[HTML][HTML] Impact of the immune system and immunotherapy in colorectal cancer
The development of cancer is a multi-step process involving the gradual loss of regulation
over the growth and functional capabilities of normal cells. Much research has been focused …
over the growth and functional capabilities of normal cells. Much research has been focused …
Nanomedicine‐based immunotherapy for the treatment of cancer metastasis
Metastasis is the leading cause of cancer‐associated death, with poor prognosis even after
extensive treatment. The dormancy of metastatic cancer cells during dissemination or after …
extensive treatment. The dormancy of metastatic cancer cells during dissemination or after …