The role of testosterone, the androgen receptor, and hypothalamic-pituitary–gonadal axis in depression in ageing Men

RL Hauger, UG Saelzler, MS Pagadala… - Reviews in Endocrine …, 2022 - Springer
Considerable research has shown that testosterone regulates many physiological systems,
modulates clinical disorders, and contributes to health outcome. However, studies on the …

Association of androgen deprivation therapy and depression in the treatment of prostate cancer: a systematic review and meta-analysis

KT Nead, S Sinha, DD Yang, PL Nguyen - Urologic Oncology: Seminars …, 2017 - Elsevier
Background There is increasing evidence that androgen deprivation therapy (ADT) may be
associated with depression. Existing studies have shown conflicting results. Methods …

[HTML][HTML] Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of …

M Faria, E Prats, JRR Ramírez, M Bellot… - Science of the Total …, 2021 - Elsevier
Fenitrothion is an organophosphorus insecticide usually found in aquatic ecosystems at
concentrations in the range of low ng/L. In this manuscript we show that 24 h exposure to …

Balancing hormone therapy: mitigating adverse effects of androgen-deprivation therapy and exploring alternatives in prostate cancer management

LM Gudenkauf, S Gray, BD Gonzalez… - American Society of …, 2024 - ascopubs.org
Androgen-deprivation therapy (ADT) is well established as the standard of care in metastatic
prostate cancer (PCa) management; however, ADT has significant adverse effects (AEs) that …

Cause of death during prostate cancer survivorship: a contemporary, US population–based analysis

AB Weiner, EV Li, AS Desai, DJ Press, EM Schaeffer - Cancer, 2021 - Wiley Online Library
BACKGROUND More than 3.6 million men in the United States harbor a diagnosis of
prostate cancer (PCa). The authors sought to provide in‐depth analyses of the causes of …

Optimizing the role of androgen deprivation therapy in advanced prostate cancer: Challenges beyond the guidelines

ND Shore, ES Antonarakis, MS Cookson… - The …, 2020 - Wiley Online Library
Background For specific clinical indications, androgen deprivation therapy (ADT) will induce
disease prostate cancer (PC) regression, relieve symptoms and prolong survival; however …

Decreasing suicide risk among patients with prostate cancer: Implications for depression, erectile dysfunction, and suicidal ideation screening

Z Klaassen, K Arora, SN Wilson, SA King… - … Oncology: Seminars and …, 2018 - Elsevier
Objective Prostate cancer is the most common malignancy among males, accounting for
19% of cancers, and the third most common cancer-related cause of death. Suicide rates in …

Effects of social support, hope and resilience on depressive symptoms within 18 months after diagnosis of prostate cancer

X Zhao, M Sun, Y Yang - Health and quality of life outcomes, 2021 - Springer
Background The prevalence of depression symptoms and related modifiable factors in
prostate cancer (PCa) are not well evaluated. We aimed to assess the effects of perceived …

Androgen deprivation therapy for prostate cancer and dementia risk: a systematic review and meta-analysis

KT Nead, S Sinha, PL Nguyen - Prostate cancer and prostatic diseases, 2017 - nature.com
Background: Androgen deprivation therapy (ADT) to treat prostate cancer may be
associated with an increased risk of dementia, but existing studies have shown conflicting …

Psychological distress in men with prostate cancer undertaking androgen deprivation therapy: modifying effects of exercise from a year-long randomized controlled …

DA Galvão, RU Newton, SK Chambers… - Prostate Cancer and …, 2021 - nature.com
Objectives To assess the long-term effects of various exercise modes on psychological
distress in men with prostate cancer on androgen deprivation therapy (ADT). Patients and …