The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

A layer of mucus covers the surface of all wet epithelia throughout the human body. Mucus is
a hydrogel mainly composed of water, mucins (glycoproteins), DNA, proteins, lipids, and cell …

Mucus is a complex biological material that lubricates and protects the human lungs,
gastrointestinal (GI) tract, vagina, eyes, and other moist mucosal surfaces. Mucus serves as …

A major role of respiratory mucus is to trap inhaled particles, including pathogens and
environmental particulates, to limit body exposure. Despite the tremendous health …

Mucus is a complex hydrogel that acts as a natural barrier to drug delivery at different
mucosal surfaces including the respiratory, gastrointestinal, and vaginal tracts. To elucidate …

This review focuses on the role and regulation of mucin glycoproteins (mucins) in airway
health and disease. Mucins are highly glycosylated macromolecules (≥ 50% carbohydrate …

Recent evidence suggests that the airway mucus gel layer may be impermeable to the viral
and synthetic gene vectors used in past inhaled gene therapy clinical trials for diseases like …

In this review, we summarize work over the past 15 years on mucin gene expression and
regulation in the lung, as well as how mucin gene expression is altered in chronic lung …

Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs,
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …

By airway surface liquid, we mean a thin fluid continuum consisting of the airway lining layer
and the alveolar lining layer, which not only serves as a protective barrier against foreign …