Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

This review deals with germ-line genes that increase susceptibility to five major types of
cancer: breast, lung, pancreatic, prostate, and colorectal cancer. Often familial, often …

An essential resource for all scientists researching cellular responses to DNA damage.•
Introduces important new material reflective of the major changes and developments that …

Micro-RNAs (miRNAs) are regulatory molecules that mediate effects by interacting with
messenger RNA (mRNA) targets. Here we show that Arabidopsis thaliana miRNA 39 (also …

High-penetrance mutations in several genes have been identified that contribute to
hereditary colorectal cancer. The role of these mutations in cancer pathogenesis is well …

Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR
genes are established cancer susceptibility genes with clinically actionable pathogenic …

RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of
the five known family members in humans give rise to debilitating disorders that are …

Bloom's syndrome is an autosomal recessive disorder characterized by prenatal and
postnatal growth deficiency, photosensitive skin changes, immune deficiency, insulin …

Cell division and organismal development are exquisitely orchestrated and regulated
processes. The dysregulation of the molecular mechanisms underlying these processes …

Histone H2AX becomes phosphorylated in chromatin domains flanking sites of DNA double-
strand breakage associated with γ-irradiation, meiotic recombination, DNA replication, and …