Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited
proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS) …

The glomerulus is a multicellular functional tissue unit (FTU) of the nephron that is
responsible for blood filtration. Each glomerulus contains multiple substructures and cell …

Abstract The Human BioMolecular Atlas Program (HuBMAP) aims to compile a Human
Reference Atlas (HRA) for the healthy adult body at the cellular level. Functional tissue units …

Glomeruli filter blood through the coordination of podocytes, mesangial cells, fenestrated
endothelial cells, and the glomerular basement membrane. Cellular changes, such as …

Imaging mass spectrometry (IMS) provides untargeted, highly multiplexed maps of
molecular distributions in tissue. Ion images are routinely presented as heatmaps and can …

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is a
rapidly advancing technology for biomedical research. As spatial resolution increases …

Objective: Pathologists rely on histochemical stains to impart contrast in thin translucent
tissue samples, revealing tissue features necessary for identifying pathological conditions …

Computational pathology is a field that has complemented various subspecialties of
diagnostic pathology over the last few years. In this article a brief analyzis the different …

The need for deep molecular and spatial characterization of tissues is growing rapidly to
study complex diseases and disorders, particularly in the context of relationships between …

Nanoparticles (NPs) are versatile tools in various applications, particularly in the biomedical
fields. To understand their behavior within biological systems, it is crucial to measure their …