The landmark 1969 discovery of nuclear RNA polymerases I, II and III in diverse eukaryotes
represented a major turning point in the field that, with subsequent elucidation of the distinct …

In eukaryotic cells, DNA is tightly packed with the help of histone proteins into chromatin.
Chromatin architecture can be modified by various post‐translational modifications of …

The modulation of DNA-protein interactions by methylation of protein-binding sites in DNA
and the occurrence in genomic imprinting, X chromosome inactivation, and fragile X …

▪ Abstract The events leading to transcription of eukaryotic protein-coding genes culminate
in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which …

Transcriptional regulation is central to the complex behavior of natural biological systems
and synthetic gene circuits. Platforms for the scalable, tunable, and simple modulation of …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

A sequence within the transcription control region of the adeno-associated virus P5
promoter has been shown to mediate transcriptional activation by the adenovirus EIA …

Cytosine methylation within CpG dinucleotides has been implicated in the regulation of
gene expression in vertebrates and, in some cases, has been shown to be causative in …

Optimized weight matrices defining four major eukaryotic promoter elements, the TATA-box,
cap signal, CCAAT-, and GC-box, are presented; they were derived by comparative …

The transcription initiation factor TFIIH is a remarkable protein complex that has a
fundamental role in the transcription of protein-coding genes as well as during the DNA …