Interplay between chromatin marks in development and disease
DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …
important roles in transcriptional regulation. Although many reports have characterized the …
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …
chromatin modification that critically contributes to the regulation of genome integrity …
Epigenomic reprogramming as a driver of malignant glioma
RE Phillips, AA Soshnev, CD Allis - Cancer cell, 2020 - cell.com
Malignant gliomas are central nervous system tumors and remain among the most treatment-
resistant cancers. Exome sequencing has revealed significant heterogeneity and important …
resistant cancers. Exome sequencing has revealed significant heterogeneity and important …
Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross …
JJ Szymanski, RT Sundby, PA Jones, D Srihari… - PLoS …, 2021 - journals.plos.org
Background The leading cause of mortality for patients with the neurofibromatosis type 1
(NF1) cancer predisposition syndrome is the development of malignant peripheral nerve …
(NF1) cancer predisposition syndrome is the development of malignant peripheral nerve …
FOXM1, MEK, and CDK4/6: New Targets for Malignant Peripheral Nerve Sheath Tumor Therapy
E Voigt, DE Quelle - International journal of molecular sciences, 2023 - mdpi.com
Malignant peripheral nerve sheath tumors (MPNSTs) are deadly sarcomas, which
desperately need effective therapies. Half of all MPNSTs arise in patients with …
desperately need effective therapies. Half of all MPNSTs arise in patients with …
Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3. 3K36M oncohistone mutation
KN Rajagopalan, X Chen… - Proceedings of the …, 2021 - National Acad Sciences
Hotspot histone H3 mutations have emerged as drivers of oncogenesis in cancers of
multiple lineages. Specifically, H3 lysine 36 to methionine (H3K36M) mutations are …
multiple lineages. Specifically, H3 lysine 36 to methionine (H3K36M) mutations are …
SWAMNA: a comprehensive platform for analysis of nucleic acid modifications
The interest in MS-based analysis of modified nucleic acids is increasing due to the
application of nucleic acids in therapeutics. However, there are few available integrated …
application of nucleic acids in therapeutics. However, there are few available integrated …
Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses
Immune checkpoint blockade (ICB) has demonstrated clinical success in “inflamed” tumors
with substantial T cell infiltrates, but tumors with an immune-desert tumor microenvironment …
with substantial T cell infiltrates, but tumors with an immune-desert tumor microenvironment …
Exposing hidden targets: combining epigenetic and immunotherapy to overcome cancer resistance
K Olino, T Park, N Ahuja - Seminars in cancer biology, 2020 - Elsevier
Advances in immunotherapy, most notably antibodies targeting the inhibitory immune
receptors cytotoxic T-lymphocyte associated protein 4 (CTLA-4/CD152), programmed death …
receptors cytotoxic T-lymphocyte associated protein 4 (CTLA-4/CD152), programmed death …
Oncohistones: a roadmap to stalled development
Since the discovery of recurrent mutations in histone H3 variants in paediatric brain tumours,
so‐called 'oncohistones' have been identified in various cancers. While their mechanism of …
so‐called 'oncohistones' have been identified in various cancers. While their mechanism of …