The detailed process and mechanism of colonic motility are still unclear, and colonic motility
disorders are associated with numerous clinical diseases. Colonic manometry is considered …

Hirschsprung's disease (HD) is a congenital disorder, characterized by aganglionosis in the
distal part of the gastrointestinal tract. Despite complete surgical resection of the aganglionic …

Characterization of high-amplitude propagating pressure waves (HAPWs or HAPCs) plays a
key role in diagnosis of colon dysmotility using any type of colonic manometry. With the …

We report the first study assessing human colon manometric features and their correlations
with changes in autonomic functioning in patients with refractory chronic constipation prior to …

Background This study was to observe the diagnostic efficacy of high resolution total colonic
intracavitary manometry (HRCM) vs colonic transit test (CTT) in the assessment of functional …

Chronic constipation can be associated with a colonic motility disorder and/or obstructive
defecation. An obstructive defecation disorder is suspected if the patient uses digital …

Optimal functional outcomes following colorectal resections are important to people suffering
from colorectal cancer or born with a colorectal disorder. In this thesis, we assessed long …

The physiological mechanisms involved in the anorectum are complex and involve a
number of key players. Impaired anorectal functions such as faecal incontinence (FI) …

The colon serves to absorb water and electrolytes, salvage nutrients after bacterial
metabolism of carbohydrates, and store intraluminal contents until elimination is socially …

Background Luminal application of 5-HT4 receptor agonists can increase peristalsis in the
guinea pig, mouse, rat and rabbit colon. Our aim in the present study was to test the effects …