DNA nanotechnology assisted nanopore-based analysis

T Ding, J Yang, V Pan, N Zhao, Z Lu, Y Ke… - Nucleic acids …, 2020 - academic.oup.com
Nanopore technology is a promising label-free detection method. However, challenges exist
for its further application in sequencing, clinical diagnostics and ultra-sensitive single …

Functional aqueous droplet networks

MJ Booth, VR Schild, FG Downs, H Bayley - Molecular BioSystems, 2017 - pubs.rsc.org
Droplet interface bilayers (DIBs), comprising individual lipid bilayers between pairs of
aqueous droplets in an oil, are proving to be a useful tool for studying membrane proteins …

Signalling and differentiation in emulsion-based multi-compartmentalized in vitro gene circuits

A Dupin, FC Simmel - Nature chemistry, 2019 - nature.com
Multicellularity enables the growth of complex life forms as it allows for the specialization of
cell types, differentiation and large-scale spatial organization. In a similar way, modular …

Programmable DNA-based Boolean logic microfluidic processing unit

W Lee, M Yu, D Lim, T Kang, Y Song - ACS nano, 2021 - ACS Publications
As molecular computing materials, information-encoded deoxyribonucleic acid (DNA)
strands provide a logical computing process by cascaded and parallel chain reactions …

Light-patterning of synthetic tissues with single droplet resolution

MJ Booth, V Restrepo Schild, SJ Box, H Bayley - Scientific reports, 2017 - nature.com
Synthetic tissues can be generated by forming networks of aqueous droplets in lipid-
containing oil. Each droplet contains a cell-free expression system and is connected to its …

Harnessing DNA computing and nanopore decoding for practical applications: from informatics to microRNA-targeting diagnostics

S Takiguchi, N Takeuchi, V Shenshin… - Chemical Society …, 2024 - pubs.rsc.org
DNA computing represents a subfield of molecular computing with the potential to become a
significant area of next-generation computation due to the high programmability inherent in …

Pattern recognition of microRNA expression in body fluids using nanopore decoding at subfemtomolar concentrations

N Takeuchi, M Hiratani, R Kawano - JACS Au, 2022 - ACS Publications
This paper describes a method for detecting microRNA (miRNA) expression patterns using
the nanopore-based DNA computing technology. miRNAs have shown promise as markers …

Development of artificial cell models using microfluidic technology and synthetic biology

K Kamiya - Micromachines, 2020 - mdpi.com
Giant lipid vesicles or liposomes are primarily composed of phospholipids and form a lipid
bilayer structurally similar to that of the cell membrane. These vesicles, like living cells, are 5 …

DNA logic operation with nanopore decoding to recognize microRNA patterns in small cell lung cancer

M Hiratani, R Kawano - Analytical chemistry, 2018 - ACS Publications
Although DNA computation has traditionally been developed for parallel calculations in
molecular analyses, this approach has recently been considered for use in diagnostic or …

Synthetic tissues

H Bayley, I Cazimoglu… - Emerging Topics in Life …, 2019 - portlandpress.com
While significant advances have been achieved with non-living synthetic cells built from the
bottom-up, less progress has been made with the fabrication of synthetic tissues built from …