Pleiotrophin (PTN) is a potent mitogenic cytokine with a high affinity for the polysaccharide
glycosaminoglycan (GAG). Although it is most strongly associated with neural development …

Pleiotrophin (PTN) is a secreted heparin-binding growth factor that through its receptor
protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) has a significant regulatory effect on …

Lymphangiogenesis is an essential physiological process but also a determining factor in
vascular-related pathological conditions. Angiopoietin-2 (Ang2) plays an important role in …

Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate
multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule …

Breast cancer is linked to hyperactivation of protein tyrosine kinases (PTKs), and recent
studies have unveiled that selective tyrosine dephosphorylation by protein tyrosine …

Protein tyrosine phosphatase receptor zeta 1 (PTPRZ1) is a type V transmembrane tyrosine
phosphatase that is highly expressed during embryonic development, while its expression …

The secreted growth factor pleiotrophin (PTN) is expressed in all species and is
evolutionarily highly conserved, suggesting that it plays a significant role in the regulation of …

Lung cancer (LC) is the leading cause of cancer-related deaths. Downregulation of CDK1, 4
and 6, key regulators of cell cycle progression, correlates with decreased LC cell …

Background Glycosylation is a multi-step post-translational enzymatic process which
enhances the functional diversity of secreted or membrane proteins and is implicated in …

Pleiotrophin (PTN) is a growth factor that appears to play an important role in prostate
cancer growth and angiogenesis. We have previously shown that decreased PTN …