Flavonoids: classification, function, and molecular mechanisms involved in bone remodelling

P Ramesh, R Jagadeesan, S Sekaran… - Frontiers in …, 2021 - frontiersin.org
Flavonoids are polyphenolic compounds spotted in various fruits, vegetables, barks, tea
plants, and stems and many more natural commodities. They have a multitude of …

Preclinical studies and clinical evaluation of compounds from the genus Epimedium for osteoporosis and bone health

IR Indran, RLZ Liang, TE Min, EL Yong - Pharmacology & therapeutics, 2016 - Elsevier
The morbidity and mortality associated with fractures due to osteoporosis or “porous bone”
contributes significantly to global healthcare costs and will increase exponentially with …

High-throughput absolute quantification sequencing revealed osteoporosis-related gut microbiota alterations in Han Chinese elderly

M Wei, C Li, Y Dai, H Zhou, Y Cui, Y Zeng… - Frontiers in cellular …, 2021 - frontiersin.org
Objective Accumulative evidence suggests that gut microbiota play an important role in bone
remodeling and hence bone health maintenance. This study aimed to explore the …

Effects of flavonoids incorporated biological macromolecules based scaffolds in bone tissue engineering

SP Soundarya, V Sanjay, AH Menon, S Dhivya… - International Journal of …, 2018 - Elsevier
Skeletal tissue damage caused by trauma, injury, or disease can often result in considerable
morbidity and the need for new, more reliable strategies for skeletal regeneration. So, to …

Molecular signaling mechanisms behind polyphenol-induced bone anabolism

E Torre - Phytochemistry Reviews, 2017 - Springer
For millennia, in the different cultures all over the world, plants have been extensively used
as a source of therapeutic agents with wide-ranging medicinal applications, thus becoming …

Luteolin attenuates glucocorticoid‐induced osteoporosis by regulating ERK/Lrp‐5/GSK‐3β signaling pathway in vivo and in vitro

Z **g, C Wang, Q Yang, X Wei, Y **… - Journal of cellular …, 2019 - Wiley Online Library
Glucocorticoid‐induced osteoporosis (GIO) is a secondary osteoporosis with extensive use
of glucocorticoids (GCs). GCs can increase bone fragility and fracture via inhibiting …

Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types

EJF Vereyken, PDAM Heijnen, W Baron… - Journal of …, 2011 - Springer
Background Macrophages play an important role in neuroinflammatory diseases such as
multiple sclerosis (MS) and spinal cord injury (SCI), being involved in both damage and …

Phenolic compounds in extra virgin olive oil stimulate human osteoblastic cell proliferation

O García-Martínez, E De Luna-Bertos… - PloS one, 2016 - journals.plos.org
In this study, we aimed to clarify the effects of phenolic compounds and extracts from
different extra virgin olive oil (EVOO) varieties obtained from fruits of different ripening stages …

Dietary nutraceuticals as backbone for bone health

MK Pandey, SC Gupta, D Karelia, PJ Gilhooley… - Biotechnology …, 2018 - Elsevier
Bone loss or osteoporosis, is a slow-progressing disease that results from dysregulation of
pro-inflammatory cytokines. The FDA has approved number of drugs for bone loss …

Association between dietary intake of flavonoid and bone mineral density in middle aged and elderly Chinese women and men

ZQ Zhang, LP He, YH Liu, J Liu, YX Su… - Osteoporosis …, 2014 - Springer
This large cross-sectional study examined the associations of dietary intakes of total
flavonoids and their subtypes with bone density in women and men. We found that greater …