1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …

Cholesterol and its relatives possessing the 1, 2-cyclopentanoperhydrophenanthrene ring
system (Figure 1) form the sterolome, which comprises a chemical library of more than 1000 …

Candida tropicalis has emerged as one of the most important Candida species. It has been
widely considered the second most virulent Candida species, only preceded by C. albicans …

Fluconazole resistance occurs in> 10% of cases of candidosis during the late stages of
AIDS. We show here in two clinical isolates that resistance was caused by defective sterol …

From each of two AIDS patients with oropharyngeal candidiasis, five Candida albicans
isolates from recurrent episodes of infection which became gradually resistant against …

The first eukaryote genome revealed three yeast cytochromes P450 (CYPs), hence the
subsequent realization that some microbial fungal genomes encode these proteins in 1 per …

Infections by the opportunistic fungal pathogen Candida albicans are widely treated with the
antifungal agent fluconazole that inhibits the biosynthesis of ergosterol, the major sterol in …

In the pathogenic yeast Candida albicans, the zinc cluster transcription factor Upc2p has
been shown to regulate the expression of ERG11 and other genes involved in ergosterol …

Candida glabrata, a yeast with intrinsically low susceptibility to azoles, frequently develops
increased azole resistance during prolonged treatment. Transposon mutagenesis revealed …

CYP 51 encodes the cytochrome P450 sterol 14α‐demethylase, an enzyme essential for
sterol biosynthesis and the target of azole fungicides. In Fusarium species, including …