Mild cognitive impairment (MCI) represents a transitional stage between healthy aging and
dementia, and affects 10–15% of the population over the age of 65. The failure of drug trials …

Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

One of the central questions in neuroscience is how communication in the brain is organized
under normal conditions and how this architecture breaks down in neurological disease. It …

The interrelationships between pathological processes and emerging clinical phenotypes in
Alzheimer's disease (AD) are important yet complicated to study, because the brain is a …

BACKGROUND: Alzheimer's disease disrupts the topological architecture of whole-brain
connectivity (ie, the connectome); however, whether this disruption is present in amnestic …

Current state-of-the-art diagnostic measures of Alzheimer's disease (AD) are invasive
(cerebrospinal fluid analysis), expensive (neuroimaging) and time-consuming …

Brain connectivity studies have revealed that highly connected 'hub'regions are particularly
vulnerable to Alzheimer pathology: they show marked amyloid-β deposition at an early …

It is well known that most brain disorders are complex diseases, such as Alzheimer's
disease (AD) and schizophrenia (SCZ). In general, brain regions and their interactions can …

There is a pressing demand for improving the quality and efficacy of health care and social
support services needed by the world's growing elderly population, especially by those …

Alzheimer's disease (AD) is increasingly recognized as a disconnection syndrome, which
leads to cognitive impairment due to the disruption of functional activity across large …