Abstract Background and Aims Osmolytes are low-molecular-weight organic solutes, a
broad group that encompasses a variety of compounds such as amino acids, tertiary …

The purpose of this review is to demonstrate the critical importance of understanding protein–
excipient interactions as a key step in the rational design of formulations to stabilize and …

Hyperosmotic stress is an often overlooked process that potentially contributes to a number
of human diseases. Whereas renal hyperosmolarity is a well-studied phenomenon, recent …

Euryhaline fishes live in a wide salinity range from freshwater to seawater and hypersaline
environments. Euryhaline fishes such as salmon, eels, and tilapia are economically …

The proper functioning of any protein depends on its three dimensional conformation which
is achieved by the accurate folding mechanism. Kee** away from the exposed stress …

Abstract Glycine betaine (N, N, N-trimethyl amine) is an osmolyte accumulated in cells that is
key for cell volume and turgor regulation, is the principal methyl donor in the methionine …

In this research, the effect of sorbitol on the structure, thermal stability and activity of native
carboxypeptidase A from bovine pancreas was investigated using ultraviolet–visible (UV …

Persister cells (persisters) are transiently tolerant to antibiotics and usually constitute a small
part of bacterial populations. Persisters remain dormant but are able to re-grow after …

Three distinct interactions between the amino acid arginine and a protein explain arginine's
ability to modulate the thermal stability of proteins. Arginine's effect on the protein unfolding …

As a multifunctional signal molecule, melatonin (N-acetyl-5-methoxytryptamine) plays many
important roles in the regulation of plant growth and development. The effect of melatonin …